Sex linked disorders are more common in men because the X

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Sex linked disorders are more common in men because the X chromosome contains more coding genes than the Y chromosome. Women have two X chromosomes one from each parent although only one of these X chromosomes is active in each cell. The other one shrivels up and becomes a small inactive fleck of DNA called a Barr body. When one of the woman’s two X chromosomes contains a loss-of-function mutation roughly half the cells in their body will still have the healthy normal wild type X chromosome functional. Which is usually enough to produce a wild type phenotype or an incompletely penentrant state which is still more viable than a full loss of function phenotype. Whereas men have only one X chromosome in all their cells. If it contains a loss-of-function mutation that gene’s function is simply lost in all their cells. Which is more likely to result in serious illness or death.

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