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45-year-old Maisie Browne noticed a change in shape and texture of a mole found on her neck. Being concerned she went to her GP for reassurance. Her doctor requested further investigations and removal of the suspected mole. Upon histological examination, it was diagnosed as basal cell carcinoma. Maisie was referred to an oncologist for treatment.
1. Describe in detail the morphology, incidence and the aetiology of a basal cell carcinoma?
2. Evaluate the pathogenesis of basal cell carcinoma?
3. Critically describe the investigations and procedure performed to remove the affected mole. Detail further examinations used to determine further spread.
4. Which histological examination would be performed on this mole?
5. Immunohistochemistry is routinely used to determine specificity and identification of carcinoma. Describe in detail this technique and describe common biological markers for basal cell carcinoma (30 marks)
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